Young Researcher Spotlight #6

by SciComm

Thibault Hirsch

Thibault Hirsch received a Master’s degree in molecular and cellular pathophysiology from the Université de Strasbourg, FR, in 2016. He then moved to the Université Catholique de Louvain, Brussels, BE, where he was awarded a PhD in October 2022. His doctoral studies at the De Duve Institute with Prof Pierre van der Bruggen focussed on understanding the roles of the transcription factor IRF4 in human CD8 T-cell function and exhaustion. He also actively collaborated on similar work about the transcription factor HELIOS, and with the Louvain Institute of Biomolecular Science and Technology (LIBST) to understand the roles of galectin-8 and endophilin-A3 on tumor immunogenicity.

Since February 2023, Thibault is a post-doctoral fellow in the van der Bruggen group at the De Duve Institute in Brussels, Belgium. The lab is interested in the ways in which T-cell functions are inhibited in cancer, and how this effect can be reversed. Thibault is concentrating on the effect of neutrophils in lung cancer patients on T-cell functions, as well as the characterization of the neutrophils’ mediators in immunosuppression. He also actively works within the INCITE consortium funded by EU Horizon2020 programme to engineer immune niches for the education of anti-tumor T-cells. Finally, he is collaborating with Lausanne University to decipher the role of transcription factor IRF8 in human CD8 T-cells.

This is Thibault’s first COST Action, and he joined the Mye-SOP and Mye-Dialogue working groups. As a member of the latter group, Thibault is coordinating the upcoming virtual journal clubs, hoping to ignite the spark for further collaboration between Mye-InfoBank’s young researchers in myeloid cell-focused hot research topics.

Photo: © Thibault Hirsch/Mye-InfoBank

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